PQQ can be detected in human viscera, reproductive organs and body fluids. Number of viscera; In body fluids or secretions, the content of milk PQQ (and its derivatives) is dozens of times higher than that of ordinary food - it is reasonable to tilt resources, and PQQ plays an important role in the growth and development of newborns.
Not surprisingly, foods rich in PQQ are all foods with high nutritional value: natto, parsley, green tea, oolong tea, kiwi fruit, etc; In addition, a small amount of PQQ was also detected in eggs and skimmed milk.
With more and more studies on the health benefits of PQQ, the content of nanogram (ng) in daily food can no longer meet the demand, and food supplements came into being. The United States approved the first PQQ dietary supplement in 2009. Since PQQ is rarely soluble in water, the supplement is composed of PQQ sodium salt (PQQ-2Na+) with better solubility; In 2018, the EU also approved PQQ-2Na+as a healthy food, suitable for adults except pregnant women and lactating women.
Food supplements can be regarded as "concentrated food". A 20 mg PQQ capsule contains 4 tons of tomatoes or 330 kg of natto (1 mg=106 ng). So far, when it comes to food supplements, we are all concerned about safety and dosage.
PQQ is mainly absorbed in the small intestine (~60%) after oral administration, and 80% of PQQ is excreted through the kidney (urine) 24 hours after oral administration; PQQ has the similar metabolic kinetics characteristics with vitamin B family, and will not accumulate in large quantities in the body.